Validated Preclinical Mouse Model for Therapeutic Testing against Multidrug-Resistant Pseudomonas aeruginosa Strains-Reference-Cited by-同舟云学术

Validated Preclinical Mouse Model for Therapeutic Testing against Multidrug-Resistant Pseudomonas aeruginosa Strains

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Warawa Jonathan M.¹²,Duan Xiaoxian¹,Anderson Charles D.¹,Sotsky Julie B.¹,Cramer Daniel E.¹,Pfeffer Tia L.¹,Guo Haixun¹³,Adcock Scott¹,Lepak Alexander J.⁴,Andes David R.⁴^ORCID,Slone Stacey A.⁵,Stromberg Arnold J.⁵,Gabbard Jon D.¹,Severson William E.¹,Lawrenz Matthew B.¹²^ORCID

Affiliation:

1. Center for Predictive Medicine for Biodefense and Emerging Infectious Diseases, University of Louisville, Louisville, Kentucky, USA

2. Department of Microbiology and Immunology, University of Louisville School of Medicine, Louisville, Kentucky, USA

3. Department of Radiology, University of Louisville School of Medicine, Louisville, Kentucky, USA

4. Department of Medicine, University of Wisconsin, Madison, Wisconsin, USA

5. Dr. Bing Zhang Department of Statistics, University of Kentucky, Lexington, Kentucky, USA

Abstract

The prevalence of antibiotic resistance among bacterial pathogens is a growing problem that necessitates the development of new antibiotics. Preclinical animal models are important tools to facilitate and speed the development of novel antimicrobials.

Funder

HHS | U.S. Food and Drug Administration

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02693-22

Reference26 articles.

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3. World Health Organization. 2017. Prioritization of pathogens to guide discovery, research and development of new antibiotics for drug-resistant bacterial infections, including tuberculosis. https://www.who.int/publications/i/item/WHO-EMP-IAU-2017.12.

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5. Antimicrobial susceptibility of Gram-negative organisms isolated from patients hospitalized in intensive care units in United States and European hospitals (2009–2011)

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