Co-Occurrence of Rare ArmA-, RmtB-, and KPC-2–Encoding Multidrug-Resistant Plasmids and Hypervirulence <i>iuc</i> Operon in ST11-KL47 Klebsiella pneumoniae-Reference-Cited by-同舟云学术

Co-Occurrence of Rare ArmA-, RmtB-, and KPC-2–Encoding Multidrug-Resistant Plasmids and Hypervirulence iuc Operon in ST11-KL47 Klebsiella pneumoniae

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhou Ying¹,Ai Wenxiu²,Guo Yinjuan¹,Wu Xiaocui¹,Wang Bingjie¹,Xu YanLei¹,Rao Lulin¹,Zhao Huilin¹,Wang Xinyi¹,Yu Fangyou¹^ORCID

Affiliation:

1. Department of Clinical Laboratory Medicine, Shanghai Pulmonary Hospital, Tongji University School of Medicine, Shanghai, People’s Republic of China

2. Department of Respiratory Medicine, First Affiliated Hospital of Wenzhou Medical University, Wenzhou, People’s Republic of China

Abstract

Carbapenemase-producing Klebsiella pneumoniae have become a great challenge for antimicrobial chemotherapy, while aminoglycosides can lower the mortality rate effectively in combination therapy with them. Unfortunately, we isolated two K. pneumoniae from blood sample of patients that not only exhibited high-level resistance to carbapenems and aminoglycosides but also showed the unusual co-occurrence of the rmtB , armA , and bla KPC-2 genes.

Funder

Shanghai pulmonary Hospital Development of Discipline-Department of Clinical Laboratory Medicine

Shanghai Sailing Program

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02371-21

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