N -(4-Methoxyphenyl)Pentanamide, a Simplified Derivative of Albendazole, Displays Anthelmintic Properties against the Nematode Toxocara canis

Author:

Silva Taís C.1,Mengarda Ana C.1,Lemes Bruna L.1,Lescano Susana A. Z.2,Souza Dalete Christine S.3,Lago João Henrique G.3,de Moraes Josué1ORCID

Affiliation:

1. Núcleo de Pesquisa em Doenças Negligenciadas, Universidade Guarulhos, Guarulhos, São Paulo, Brazil

2. Instituto de Medicina Tropical, Faculdade de Medicina, Universidade de São Paulo, São Paulo, São Paulo, Brazil

3. Centro de Ciências Naturais e Humanas, Universidade Federal do ABC, Santo André, São Paulo, Brazil

Abstract

Infections caused by parasitic helminths have enormous health, social, and economic impacts worldwide. The treatment and control of these diseases have been dependent on a limited set of drugs, many of which have become less effective, necessitating the search for novel anthelmintic agents.

Funder

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

MCTI | Conselho Nacional de Desenvolvimento Científico e Tecnológico

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference29 articles.

1. FDA-Approved Antiparasitic Drugs in the 21st Century: A Success for Helminthiasis?

2. Recent trends in praziquantel nanoformulations for helminthiasis treatment

3. World Health Organization. 2022. Soil-transmitted helminth infections. World Health Organization, Geneva, Switzerland. https://www.who.int/news-room/fact-sheets/detail/soil-transmitted-helminth-infections.

4. Whipworm and roundworm infections

5. World Health Organization. 2021. Ending the neglect to attain the sustainable development goals: a road map for neglected tropical diseases 2021-2030. World Health Organization, Geneva, Switzerland. https://www.who.int/publications/i/item/9789240010352.

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