Type IV Pilus-Mediated Inhibition of Acinetobacter baumannii Biofilm Formation by Phenothiazine Compounds

Author:

Vo Nam1,Sidner Benjamin S.1,Yu Yafan12,Piepenbrink Kurt H.12345ORCID

Affiliation:

1. Department of Biochemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

2. Department of Food Science and Technology, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

3. Department of Chemistry, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

4. Nebraska Food for Health Center, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

5. Center for Integrated Biomolecular Communication, University of Nebraska-Lincoln, Lincoln, Nebraska, USA

Abstract

Acinetobacter infections are a growing burden on health care systems worldwide due to increasing antimicrobial resistance through multiple mechanisms. Biofilm formation is an established mechanism of antimicrobial resistance, and its inhibition has the potential to potentiate the use of existing drugs against pathogenic Acinetobacter .

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

HHS | NIH | National Institute of General Medical Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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