Inflammatory Endotype-Associated Airway Resistome in Chronic Obstructive Pulmonary Disease

Author:

Yi Xinzhu1,Li Yanjun2,Liu Haiyue3,Liu Xiaomin1,Yang Junhao1,Gao Jingyuan1,Yang Yuqiong4,Liang Zhenyu4,Wang Fengyan4,Chen Dandan5,Wang Lingwei5,Shi Weijuan4,Lam David C. L.6,Stampfli Martin R.7,Jones Paul W.8,Chen Rongchang45,Wang Zhang1ORCID

Affiliation:

1. Institute of Ecological Sciences, School of Life Sciences, South China Normal University, Guangzhou, China

2. Emergency Department, Shenzhen Traditional Chinese Medicine Hospital, Shenzhen, China

3. Xiamen Key Laboratory of Genetic Testing, Department of Laboratory Medicine, the First Affiliated Hospital of Xiamen University, Xiamen, China

4. First Affiliated Hospital of Guangzhou Medical University, National Clinical Research Center for Respiratory Disease, Guangzhou Institute of Respiratory Health, State Key Laboratory of Respiratory Disease, Guangzhou, China

5. Key Laboratory of Shenzhen Respiratory Diseases, Institute of Shenzhen Respiratory Diseases, Shenzhen People’s Hospital, Shenzhen, China

6. Department of Medicine, Li Ka Shing Faculty of Medicine, University of Hong Kong, Hong Kong SAR, China

7. Department of Medicine, Firestone Institute of Respiratory Health at St. Joseph’s Healthcare, McMaster University, Hamilton, Ontario, Canada

8. Institute for Infection and Immunity, St George’s, University of London, London, United Kingdom

Abstract

Antibiotics are commonly prescribed for both acute and long-term prophylactic treatment in chronic airway disorders, such as chronic obstructive pulmonary disease (COPD), and the rapid growth of antibiotic resistance is alarming globally. The airway harbors a diverse collection of microorganisms known as microbiota, which serve as a reservoir for antibiotic resistance genes or the resistome.

Funder

MOST | National Key Research and Development Program of China

National Natural Science Foundation of China

Science and Technology Foundation of Guangdong Province

Shenzhen Science Technology and Innovative Commission

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference18 articles.

1. Chronic obstructive pulmonary disease: current burden and future projections

2. Chronic Obstructive Pulmonary Disease Phenotypes

3. Treatable traits: toward precision medicine of chronic airway diseases

4. Inflammatory endotypes in COPD

5. National Institute for Health and Care Excellence. 2010. Chronic obstructive pulmonary disease in over 16s: diagnosis and management. https://www.nice.org.uk/guidance/cg101. Accessed October 1 2021.

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