Sequencing Directly from Clinical Specimens Reveals Genetic Variations in HCMV-Encoded Chemokine Receptor US28 That May Influence Antibody Levels and Interactions with Human Chemokines

Author:

Waters Shelley1ORCID,Agostino Mark12,Lee Silvia13,Ariyanto Ibnu4,Kresoje Nina5,Leary Shay6,Munyard Kylie1,Gaudieri Silvana678,Gaff Jessica1,Irish Ashley9,Keil Anthony D.3,Price Patricia1ORCID,Allcock Richard J. N.510

Affiliation:

1. Curtin Medical School, Curtin Health Innovation Research Institute, Curtin University, Bentley, Western Australia, Australia

2. Curtin Institute for Computation, Curtin University, Bentley, Western Australia, Australia

3. Department of Microbiology, PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia

4. Virology and Cancer Pathobiology Research Center, Faculty of Medicine, Universitas Indonesia, Jakarta, Indonesia

5. School of Biomedical Sciences, University of Western Australia, Perth, Western Australia, Australia

6. Institute for Immunology and Infectious Diseases, Murdoch University, Murdoch, Western Australia, Australia

7. School of Human Sciences, University of Western Australia, Perth, Western Australia, Australia

8. Department of Medicine, Division of Infectious Diseases, Vanderbilt University Medical Center, Nashville, Tennessee, USA

9. Department of Nephrology, Fiona Stanley Hospital, Murdoch, Western Australia, Australia

10. Department of Diagnostic Genomics, PathWest Laboratory Medicine WA, Nedlands, Western Australia, Australia

Abstract

Human cytomegalovirus (HCMV) is a common viral pathogen of solid organ transplant recipients, neonates, and HIV-infected individuals. HCMV encodes homologs of several host genes with the potential to influence viral persistence and/or pathogenesis.

Funder

Department of Health, Australian Government | National Health and Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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