The Existing Drug Nifuroxazide as an Antischistosomal Agent: In Vitro , In Vivo , and In Silico Studies of Macromolecular Targets-Reference-Cited by-同舟云学术

The Existing Drug Nifuroxazide as an Antischistosomal Agent: In Vitro , In Vivo , and In Silico Studies of Macromolecular Targets

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Roquini Vinícius¹,Mengarda Ana C.¹,Cajas Rayssa A.¹,Martins-da-Silva Milene F.¹,Godoy-Silva Julia¹,Santos Gustavo A.¹,Espírito-Santo Maria Cristina C.²³,Pavani Thais F. A.⁴,Melo Vanusa A.⁴,Salvadori Maria C.⁵,Teixeira Fernanda S.⁵,Rando Daniela G. G.⁶,de Moraes Josué¹^ORCID

Affiliation:

1. Research Center on Neglected Diseases, Guarulhos University, Guarulhos, São Paulo, Brazil

2. Laboratory of Immunopathology of Schistosomiasis (LIM-06), Department of Infectious and Parasitic Diseases, Faculty of Medicine, University of São Paulo, São Paulo, São Paulo, Brazil

3. Laboratory of Helminthology, Institute of Tropical Medicine, University of São Paulo, São Paulo, São Paulo, Brazil

4. Biological Chemistry Post-Graduate Course, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil

5. Institute of Physics, University of São Paulo, São Paulo, São Paulo, Brazil

6. Chemico-Pharmaceutical Research Group, Institute of Environmental, Chemical and Pharmaceutical Sciences, Federal University of São Paulo, Diadema, São Paulo, Brazil

Abstract

The increasing recognition of the burden imposed by helminthiasis, associated with the limited therapeutic arsenal, has led to initiatives and strategies to research and develop new drugs for the treatment of schistosomiasis. One of these strategies is drug repurposing, which considers low-risk compounds with potentially reduced costs and shorter time for development.

Funder

Conselho Nacional de Desenvolvimento Científico e Tecnológico

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior

Fundação de Amparo à Pesquisa do Estado de São Paulo

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01393-23

Reference64 articles.

1. Schistosomiasis