A Multiwell-Plate Caenorhabditis elegans Assay for Assessing the Therapeutic Potential of Bacteriophages against Clinical Pathogens-Reference-Cited by-同舟云学术

A Multiwell-Plate Caenorhabditis elegans Assay for Assessing the Therapeutic Potential of Bacteriophages against Clinical Pathogens

Published:2022-02-23 Issue:1 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Manohar Prasanth¹²,Loh Belinda¹^ORCID,Elangovan Namasivayam³,Loganathan Archana⁴,Nachimuthu Ramesh⁴,Leptihn Sebastian¹⁵⁶^ORCID

Affiliation:

1. Zhejiang University-University of Edinburgh (ZJE) Institute, Zhejiang University, School of Medicine, Haining, Zhejiang, People’s Republic of China

2. The Second Affiliated Hospital Zhejiang University (SAHZU), School of Medicine, Hangzhou, Zhejiang, People’s Republic of China

3. Department of Biotechnology, School of Bioscience, Periyar University, Salem, Tamil Nadu, India

4. Antibiotic Resistance and Phage Therapy Lab, Department of Biomedical Science, School of Biosciences and Technology, Vellore, Tamil Nadu, India

5. Department of Infectious Diseases, Sir Run Department Shaw Hospital, Zhejiang University, School of Medicine, Hangzhou, Zhejiang, People’s Republic of China

6. University of Edinburgh Medical School, Biomedical Sciences, College of Medicine & Veterinary Medicine, The University of Edinburgh, Edinburgh, United Kingdom

Abstract

Validating the efficacy and safety of phages prior to clinical application is crucial to see phage therapy in practice. Current animal models include mice and insect larvae, which pose ethical or technical challenges.

Funder

VIT University

Zhejiang Province Postdoctoral Research Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01393-21

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