<i>In Vivo</i> Emergence of Dual Resistance to Rifampin and Levofloxacin in Osteoarticular <i>Cutibacterium avidum</i>-Reference-Cited by-同舟云学术

In Vivo Emergence of Dual Resistance to Rifampin and Levofloxacin in Osteoarticular Cutibacterium avidum

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Cunningham Scott A.¹,Rodriguez Christophe²³,Woerther Paul-Louis²³^ORCID,Menigaux Christophe⁴,Bauer Thomas⁴,Herrmann Jean-Louis⁵⁶,Rottman Martin⁵⁶^ORCID,Roux Anne-Laure⁶⁷,Gaillard Jean-Louis⁶⁷,Patel Robin¹⁸^ORCID,El Sayed Faten⁶⁷^ORCID

Affiliation:

1. Division of Clinical Microbiology, Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA

2. NGS Platform, IMRB, CHU Henri Mondor, Créteil, France

3. Institut Mondor de Recherche Biomédicale, Inserm U955, Créteil, France

4. APHP, GHU Paris Saclay, Hôpital Ambroise Paré, Orthopedic Surgery Department, Boulogne-Billancourt, France

5. APHP, GHU Paris Saclay, Hôpital Raymond Poincaré, Microbiology Department, Garches, France

6. Université Paris-Saclay, UVSQ, Inserm, Infection et Inflammation, Montigny-Le-Bretonneux, France

7. APHP, GHU Paris Saclay, Hôpital Ambroise Paré, Microbiology Department, Boulogne-Billancourt, France

8. Division of Public Health, Infectious Diseases and Occupational Medicine, Mayo Clinic, Rochester, Minnesota, USA

Abstract

In this study, we report for the first time the in vivo emergence of dual resistance to levofloxacin and rifampin in C. avidum isolated from a patient who received both antibiotics orally in the setting of a salvage debridement and implant retention of an ODRI. Aside from the molecular insights reported here, this study highlights potential limitations of the combination of oral rifampin and levofloxacin in patients undergoing these surgical procedures and the potential need to evaluate specific optimal therapy for emerging ODRI pathogens.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03687-22

Reference21 articles.

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3. Clinical and Biological Features of Cutibacterium (Formerly Propionibacterium) avidum , an Underrecognized Microorganism

4. Propionibacterium/Cutibacterium species–related positive samples, identification, clinical and resistance features: a 10-year survey in a French hospital

5. Structural Mechanism for Rifampicin Inhibition of Bacterial RNA Polymerase

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