Correlation Analysis between Gut Microbiota Alterations and the Cytokine Response in Patients with Coronavirus Disease during Hospitalization-Reference-Cited by-同舟云学术

Correlation Analysis between Gut Microbiota Alterations and the Cytokine Response in Patients with Coronavirus Disease during Hospitalization

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Mizutani Taketoshi¹²^ORCID,Ishizaka Aya¹,Koga Michiko¹,Ikeuchi Kazuhiko³,Saito Makoto³^ORCID,Adachi Eisuke³,Yamayoshi Seiya⁴⁵^ORCID,Iwatsuki-Horimoto Kiyoko⁴^ORCID,Yasuhara Atsuhiro⁴,Kiyono Hiroshi⁶⁷⁸,Matano Tetsuro⁹¹⁰^ORCID,Suzuki Yutaka²,Tsutsumi Takeya¹,Kawaoka Yoshihiro⁴⁵^ORCID,Yotsuyanagi Hiroshi¹³

Affiliation:

1. Division of Infectious Diseases, Advanced Clinical Research Center, the Institute of Medical Science, The University of Tokyo, Tokyo, Japan

2. Department of Computational Biology and Medical Sciences, Graduate School of Frontier Sciences, The University of Tokyo, Chiba, Japan

3. Department of Infectious Diseases and Applied Immunology, IMSUT Hospital of Institute of Medical Science, the University of Tokyo, Tokyo, Japan

4. Division of Virology, Department of Microbiology and Immunology, Institute of Medical Science, The University of Tokyo, Japan

5. Research Center for Global Viral Infections, National Center for Global Health and Medicine, Tokyo, Japan

6. International Research and Development Center for Mucosal Vaccines, the Institute of Medical Science, The University of Tokyo, Tokyo, Japan

7. CU-UCSD Center for Mucosal Immunology, Allergy and Vaccines (cMAV), Department of Medicine, University of California San Diego, San Diego, California, USA

8. Future Medicine Education and Research Organization, Chiba University, Chiba, Japan

9. AIDS Research Center, National Institute of Infectious Diseases, Tokyo, Japan

10. Department of AIDS Vaccine Development, IMSUT Hospital, the Institute of Medical Science, The University of Tokyo, Tokyo, Japan

Abstract

There is growing evidence that the commensal microbiota of the gastrointestinal and respiratory tracts regulates local and systemic inflammation (gut-lung axis). COVID-19 is primarily a respiratory disease, but the involvement of microbiota changes in the pathogenesis of this disease remains unclear.

Funder

MEXT | Japan Society for the Promotion of Science

MEXT | JST | Science and Technology Research Partnership for Sustainable Development

Japan Agency for Medical Research and Development

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01689-21

Reference35 articles.

1. SARS-CoV-2 productively infects human gut enterocytes