Vibrio cholerae Alkalizes Its Environment via Citrate Metabolism to Inhibit Enteric Growth <i>In Vitro</i>-Reference-Cited by-同舟云学术

Vibrio cholerae Alkalizes Its Environment via Citrate Metabolism to Inhibit Enteric Growth In Vitro

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kostiuk Benjamin¹,Becker Mark E.²^ORCID,Churaman Candice N.³,Black Joshua J.⁴^ORCID,Payne Shelley M.⁵⁶^ORCID,Pukatzki Stefan⁷^ORCID,Koestler Benjamin J.³^ORCID

Affiliation:

1. Department of Medical Microbiology and Immunology, 6-020 Katz Group Centre, University of Alberta, Edmonton, Alberta, Canada

2. Department of Cell and Developmental Biology, Northwestern University Feinberg School of Medicine, Chicago, Illinois, USA

3. Department of Biological Sciences, Western Michigan University, Kalamazoo, Michigan, USA

4. Department of Molecular Biology and Genetics, Johns Hopkins University School of Medicine, Baltimore, Maryland, USA

5. Department of Molecular Biosciences, The University of Texas at Austin, Austin, Texas, USA

6. Institute for Cellular and Molecular Biology, The University of Texas at Austin, Austin, Texas, USA

7. Department of Biology, The City College of New York, New York, New York, USA

Abstract

Vibrio cholerae must compete with other bacteria in order to cause disease. Here, we show that V. cholerae creates an alkaline environment, which is able to inhibit the growth of other enteric bacteria. We demonstrate that V. cholerae environmental alkalization is linked to the capacity of the bacteria to metabolize citrate. This behavior could potentially contribute to V. cholerae’s ability to colonize the human intestine.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Gouvernement du Canada | Canadian Institutes of Health Research

Gouvernement du Canada | Natural Sciences and Engineering Research Council of Canada

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04917-22

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