Emergence of a Fatal ST11-KL64 Tigecycline-Resistant Hypervirulent Klebsiella pneumoniae Clone Cocarrying bla NDM and bla KPC in Plasmids-Reference-Cited by-同舟云学术

Emergence of a Fatal ST11-KL64 Tigecycline-Resistant Hypervirulent Klebsiella pneumoniae Clone Cocarrying bla _NDM and bla _KPC in Plasmids

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Huang Jinzhu¹,Yi Miao¹,Yuan Yaling¹,Xia Peiwen¹,Yang Bingxue¹,Liao Jiajia¹,Dang Zijun¹,Luo Shengli¹,Xia Yun¹^ORCID

Affiliation:

1. Department of Laboratory Medicine, The First Affiliated Hospital of Chongqing Medical University, Chongqing, China

Abstract

Infections with CRKP coproducing KPC and NDM currently have limited clinical antibacterial options, and tigecycline is used as the last line of defense for therapy. However, this study found that CR-hvKP infection with tigecycline resistance, which may lead to many bacteria being resistant to most commonly used antibiotics, brought significant challenges to clinical treatment. The clonal propagation of ST11-KL64 CRKP should receive sufficient attention.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02539-22

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