Protein Kinase C Inhibitors Reduce SARS-CoV-2 Replication in Cultured Cells-Reference-Cited by-同舟云学术

Protein Kinase C Inhibitors Reduce SARS-CoV-2 Replication in Cultured Cells

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Huang Changbai¹²,Feng Fei³,Shi Yongxia⁴,Li Wenhui²,Wang Ziqiao³,Zhu Yunkai³,Yuan Shuai⁴,Hu Dandan⁴,Dai Jun⁴,Jiang Qiqi²,Zhang Rong³,Liu Chao¹⁵^ORCID,Zhang Ping¹²^ORCID

Affiliation:

1. Key Laboratory of Tropical Diseases Control (Sun Yat-sen University), Ministry of Education, Guangzhou, China

2. Department of Immunology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

3. Key Laboratory of Medical Molecular Virology (MOE/NHC/CAMS), School of Basic Medical Sciences, Shanghai Medical College, Fudan University, Shanghai, China

4. Health and Quarantine Institute, Guangzhou Customs Technology Centre, Guangzhou, China

5. Department of Microbiology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

Abstract

There is an urgent need for effective therapeutic drugs to control the pandemic caused by severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2). We found that several inhibitors of protein kinases C (PKCs) dramatically decrease the replication of SARS-CoV-2 in cultured cells.

Funder

National Natural Science Foundation of China

MOST | National Key Research and Development Program of China

Bureau of Science and Information Technology of Guangzhou Municipality | Guangzhou Municipal Science and Technology Project

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01056-22

Reference36 articles.

1. The species Severe acute respiratory syndrome-related coronavirus: classifying 2019-nCoV and naming it SARS-CoV-2