Predictive Power of Long-Read Whole-Genome Sequencing for Rapid Diagnostics of Multidrug-Resistant Brachyspira hyodysenteriae Strains-Reference-Cited by-同舟云学术

Predictive Power of Long-Read Whole-Genome Sequencing for Rapid Diagnostics of Multidrug-Resistant Brachyspira hyodysenteriae Strains

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Vereecke Nick¹²^ORCID,Botteldoorn Nadine³,Brossé Charlotte³,Bonckaert Caroline³,Nauwynck Hans¹²,Haesebrouck Freddy⁴,Boyen Filip⁴,Maes Dominiek⁵,Theuns Sebastiaan¹²

Affiliation:

1. Laboratory of Virology, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

2. PathoSense BV, Lier, Belgium

3. Animal Health Care Flanders, Lier, Belgium

4. Department of Pathobiology, Pharmacology and Zoological Medicine, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

5. Unit of Porcine Health Management, Faculty of Veterinary Medicine, Ghent University, Merelbeke, Belgium

Abstract

Diagnostics for swine dysentery rely on the identification of Brachyspira species using molecular techniques. Nevertheless, no quick diagnostic tools are available for antimicrobial susceptibility testing due to extended growth requirements (7 to 14 days).

Funder

Baekeland

Veepeiler Varken

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04123-22

Reference78 articles.

1. Whole-Genome Sequencing of Brachyspira hyodysenteriae Isolates From England and Wales Reveals Similarities to European Isolates and Mutations Associated With Reduced Sensitivity to Antimicrobials

2. Swine dysentery disease mechanism: Brachyspira hampsonii impairs the colonic immune and epithelial repair responses to induce lesions