When Combined with Pentamidine, Originally Ineffective Linezolid Becomes Active in Carbapenem-Resistant Enterobacteriaceae

Author:

Tang Miran1,Qian Changrui2,Zhang Xiaotuan1,Liu Yan1,Pan Wei1ORCID,Yao Zhuocheng3,Zeng Weiliang1,Xu Chunquan1,Zhou Tieli1ORCID

Affiliation:

1. Department of Clinical Laboratory, The First Affiliated Hospital of Wenzhou Medical University; Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province, China

2. School of Basic Medical Sciences, Wenzhou Medical University, Wenzhou, Zhejiang Province, China

3. Department of Medical Lab Science, School of Laboratory Medicine and Life Science, Wenzhou Medical University, Wenzhou, Zhejiang Province, China

Abstract

The multidrug resistance and biofilm formation of Gram-negative bacteria (GNB) may lead to incurable “superbug” infections. Drug combinations, with the potential to augment the original treatment ranges of drugs, are alternative treatment strategies against GNB.

Funder

Key Laboratory of Clinical Laboratory Diagnosis and Translational Research of Zhejiang Province

General projects of Zhejiang Provincial Department of Education

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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