Reduced Staphylococcus Abundance Characterizes the Lesional Microbiome of Actinic Keratosis Patients after Field-Directed Therapies-Reference-Cited by-同舟云学术

Reduced Staphylococcus Abundance Characterizes the Lesional Microbiome of Actinic Keratosis Patients after Field-Directed Therapies

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kehrmann Jan¹^ORCID,Koch Fiona²,Zumdick Skrollan¹,Höwner Anna²,Best Lara¹,Masshöfer Lars³,Scharfenberg Sarah²,Zeschnigk Michael³,Becker Jürgen C.⁴⁵,Schadendorf Dirk²⁵,Buer Jan¹,Roesch Alexander²⁵

Affiliation:

1. Institute of Medical Microbiology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

2. Department of Dermatology, University Hospital Essen, University Duisburg-Essen and German Cancer Partner site Essen/Düsseldorf, Essen, Germany

3. Institute for Human Genetics, University Hospital Essen, University of Duisburg-Essen, Essen, Germany

4. Departments of Translational Skin Cancer Research and Dermatology, University Hospital Essen, Essen, Germany

5. German Cancer Consortium (DKTK), Partner Site Essen/Düsseldorf and German Cancer Research Center (DKFZ), Heidelberg, Germany

Abstract

The relevance of the skin microbiome for development of actinic keratosis (AK), its progression into squamous skin cancer, and for field-directed treatment response is unknown. An overabundance of staphylococci characterizes the skin microbiome of AK lesions.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.04401-22

Reference30 articles.

1. The global burden of skin cancer: A longitudinal analysis from the Global Burden of Disease Study, 1990–2017

2. Cutaneous squamous cell carcinoma

3. Chronic Inflammation in Skin Malignancies

4. The skin microbiome

5. Role of Bak in UV-induced apoptosis in skin cancer and abrogation by HPV E6 proteins

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