The Anticancer Drug Bleomycin Shows Potent Antifungal Activity by Altering Phospholipid Biosynthesis

Author:

Pokharel Mona1,Konarzewska Paulina1,Roberge Jacques Y.2,Han Gil-Soo3,Wang Yina1,Carman George M.3,Xue Chaoyang134ORCID

Affiliation:

1. Public Health Research Institute, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

2. Molecular Design and Synthesis Core, Rutgers University Biomolecular Innovations Cores, Office for Research, Rutgers University, Piscataway, New Jersey, USA

3. Rutgers Center for Lipid Research, New Jersey Institute for Food, Nutrition and Health, Rutgers University, New Brunswick, New Jersey, USA

4. Department of Microbiology, Biochemistry and Molecular Genetics, New Jersey Medical School, Rutgers University, Newark, New Jersey, USA

Abstract

Invasive fungal pathogens cause significant morbidity and mortality, with over 1.5 million deaths annually. Because fungi are eukaryotes that share much of their cellular machinery with the host, our armamentarium of antifungal drugs is highly limited, with only three classes of antifungal drugs available.

Funder

HHS | National Institutes of Health

NIH

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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