Week 96 Results of Switching from Tenofovir Disoproxil Fumarate-Based Antiretroviral Therapy to Coformulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide among HIV/Hepatitis B Virus-Coinfected Patients-Reference-Cited by-同舟云学术

Week 96 Results of Switching from Tenofovir Disoproxil Fumarate-Based Antiretroviral Therapy to Coformulated Elvitegravir, Cobicistat, Emtricitabine, and Tenofovir Alafenamide among HIV/Hepatitis B Virus-Coinfected Patients

Published:2023-06-15 Issue:3 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Huang Yu-Shan¹,Cheng Chien-Yu²³,Sun Hsin-Yun¹,Cheng Shu-Hsing²⁴,Lu Po-Liang⁵,Lee Chen-Hsiang⁶,Lee Yuan-Ti⁷⁸,Tsai Hung-Chin⁹,Yang Chia-Jui¹⁰¹¹,Liu Chun-Eng¹²,Liou Bo-Huang¹³,Lin Shih-Ping¹⁴,Huang Sung-Hsi¹⁵¹⁶^ORCID,Ho Mao-Wang¹⁷,Tang Hung-Jen¹⁸¹⁹,Hung Chien-Ching¹¹⁶²⁰^ORCID,

Affiliation:

1. Department of Internal Medicine, National Taiwan University Hospital and National Taiwan University College of Medicine, Taipei, Taiwan

2. Department of Infectious Diseases, Taoyuan General Hospital, Ministry of Health and Welfare, Taoyuan, Taiwan

3. School of Public Health, National Yang Ming Chiao Tung University, Taipei, Taiwan

4. School of Public Health, Taipei Medical University, Taipei, Taiwan

5. Department of Internal Medicine, Kaohsiung Medical University and College of Medicine, Kaohsiung, Taiwan

6. Department of Internal Medicine, Kaohsiung Chang Gung Memorial Hospital and Chang Gung University College of Medicine, Kaohsiung, Taiwan

7. Department of Internal Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

8. School of Medicine, Chung Shan Medical University, Taichung, Taiwan

9. Department of Internal Medicine, Kaohsiung Veterans General Hospital, Kaohsiung, Taiwan

10. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

11. Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan

12. Department of Internal Medicine, Changhua Christian Hospital, Changhua, Taiwan

13. Department of Internal Medicine, Hsinchu MacKay Memorial Hospital, Hsinchu City, Taiwan

14. Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan

15. Department of Internal Medicine, National Taiwan University Hospital Hsinchu Branch, Hsinchu, Taiwan

16. Department of Tropical Medicine and Parasitology, National Taiwan University College of Medicine, Taipei, Taiwan

17. Department of Internal Medicine, China Medical University Hospital, Taichung, Taiwan

18. Department of Internal Medicine, Chi Mei Medical Center, Tainan, Taiwan

19. Department of Health and Nutrition, Chia Nan University of Pharmacy and Sciences, Tainan, Taiwan

20. Department of Internal Medicine, National Taiwan University Hospital Yunlin Branch, Yunlin, Taiwan

Abstract

Elvitegravir/cobicistat/emtricitabine/tenofovir alafenamide as a maintenance therapy showed durable and high rates of viral suppression for HIV/HBV-coinfected patients, with only 5.1% and 2.2% of patients having HBV DNA of ≥20 IU/mL and HIV RNA of ≥50 copies/mL, respectively, at 96 weeks. Our study fills the data gap on the long-term clinical effectiveness of tenofovir alafenamide-containing antiretroviral therapy in people living with HIV who have HBV coinfection.

Funder

Gilead Sciences

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.05125-22

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