Polysaccharide of Ganoderma lucidum Ameliorates Cachectic Myopathy Induced by the Combination Cisplatin plus Docetaxel in Mice

Author:

Wu Sung-Yu12,Ou Chu-Chyn3,Lee Meng-Lin4,Hsin I-Lun1,Kang Yu-Ting1,Jan Ming-Shiou145,Ko Jiunn-Liang16ORCID

Affiliation:

1. Institute of Medicine, Chung Shan Medical University, Taichung, Taiwan

2. Department of Ophthalmology, Chung Shan Medical University Hospital, Taichung, Taiwan

3. Department of Nutrition, Chung Shan Medical University, Taichung, Taiwan

4. Institute of Biochemistry, Microbiology and Immunology, Chung Shan Medical University, Taichung, Taiwan

5. Department of Health Industry Technology Management, Chung Shan Medical University, Taichung, Taiwan

6. Department of Medical Oncology and Chest Medicine, Chung Shan Medical University Hospital, Taichung, Taiwan

Abstract

Cachexia is a multifactorial syndrome driven by metabolic dysregulation, anorexia, systemic inflammation, and insulin resistance. Approximately 80% of patients with advanced cancer have cachexia, and cachexia is the cause of death in 30% of cancer patients.

Funder

Ministry of Science and Technology, Taiwan

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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