Generation of an Attenuated Chimeric Bat Influenza A Virus Live-Vaccine Prototype-Reference-Cited by-同舟云学术

Generation of an Attenuated Chimeric Bat Influenza A Virus Live-Vaccine Prototype

Published:2022-12-21 Issue:6 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Ran Wei¹²,Schön Jacob³,Ciminski Kevin¹²^ORCID,Kraft Julian¹²,Kessler Susanne¹²,Euchner Sophie¹²,Hoffmann Donata³,Pohlmann Anne³,Beer Martin³^ORCID,Schwemmle Martin¹²^ORCID,Giese Sebastian¹²^ORCID

Affiliation:

1. Institute of Virology, University Medical Center Freiburg, Freiburg, Germany

2. Faculty of Medicine, University of Freiburg, Freiburg, Germany

3. Institute of Diagnostic Virology, Friedrich Loeffler Institute, Federal Research Institute for Animal Health, Greifswald-Insel Riems, Germany

Abstract

Recurring influenza A virus outbreaks in livestock, particularly in swine and chickens, pose a constant threat to humans. Live attenuated influenza vaccines (LAIVs) might be a potent tool to prevent epizootic outbreaks and the resulting human IAV infections; however, LAIVs have several disadvantages, especially in terms of reassortment with circulating IAVs.

Funder

Deutsche Forschungsgemeinschaft

China Scholarship Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01424-22

Reference29 articles.

1. Antigenic and Genetic Characteristics of Swine-Origin 2009 A(H1N1) Influenza Viruses Circulating in Humans

2. Up to new tricks – A review of cross-species transmission of influenza A viruses

3. Zoonotic Potential of Influenza A Viruses: A Comprehensive Overview

4. Getting the flu: 5 key facts about influenza virus evolution

5. Influenza A Viruses: Understanding Human Host Determinants

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