Susceptibility of Ugandan Plasmodium falciparum Isolates to the Antimalarial Drug Pipeline

Author:

Kreutzfeld Oriana1ORCID,Tumwebaze Patrick K.2,Okitwi Martin2,Orena Stephen2,Byaruhanga Oswald2,Katairo Thomas2,Conrad Melissa D.1ORCID,Rasmussen Stephanie A.3,Legac Jennifer1,Aydemir Ozkan4,Giesbrecht David5,Forte Barbara6,Campbell Peter6,Smith Alasdair6,Kano Hiroki7,Nsobya Samuel L.2,Blasco Benjamin8,Duffey Maelle8,Bailey Jeffrey A.5,Cooper Roland A.3ORCID,Rosenthal Philip J.1ORCID

Affiliation:

1. University of California, San Francisco, San Francisco, California, USA

2. Infectious Diseases Research Collaboration, Kampala, Uganda

3. Dominican University of California, San Rafael, California, USA

4. Program in Molecular Medicine, University of Massachusetts Medical School, Worcester, Massachusetts, USA

5. Brown University, Providence, Rhode Island, USA

6. Wellcome Centre for Anti-Infectives Research, Division of Biological Chemistry and Drug Discovery, University of Dundee, Dundee, United Kingdom

7. Mitsubishi Tanabe Pharma Corporation, Yokohama, Japan

8. Medicines for Malaria Venture, Geneva, Switzerland

Abstract

Drug resistance necessitates the development of new antimalarial drugs. It is important to assess the activities of compounds under development against parasites now causing disease in Africa, where most malaria cases occur, and to determine if mutations in these parasites may limit the efficacies of new agents.

Funder

National Institute of Health

Medicines for Malaria Venture

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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