Modulation of Gut Microbiota Metabolism in Obesity-Related Type 2 Diabetes Reduces Osteomyelitis Severity-Reference-Cited by-同舟云学术

Modulation of Gut Microbiota Metabolism in Obesity-Related Type 2 Diabetes Reduces Osteomyelitis Severity

Published:2022-04-27 Issue:2 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Bui Tina I.¹^ORCID,Gill Ann Lindley¹,Mooney Robert A.²³,Gill Steven R.¹³^ORCID

Affiliation:

1. Department of Microbiology and Immunology, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

2. Department of Pathology and Laboratory Medicine, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

3. Center for Musculoskeletal Research, University of Rochester School of Medicine and Dentistry, Rochester, New York, USA

Abstract

Individuals with obesity-related type 2 diabetes (obesity/T2D) are at a five times increased risk for invasive Staphylococcus aureus osteomyelitis (bone infection) following orthopedic surgeries. With increasing antibiotic resistance and limited discoveries of novel antibiotics, it is imperative that we explore other avenues for therapeutics.

Funder

AO Trauma Clinical Priority on Bone Infection

HHS | NIH | National Institute of Dental and Craniofacial Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00170-22

Reference88 articles.

1. Apoptosis is increased in a model of diabetes-impaired wound healing in genetically diabetic mice

2. Wound Healing in Mice with High-Fat Diet- orobGene-Induced Diabetes-Obesity Syndromes: A Comparative Study