Characteristics of Gut Microbiota in Patients with GH-Secreting Pituitary Adenoma

Author:

Lin Ben1,Wang Meng2,Gao Renyuan3,Ye Zhao1,Yu Yifei2,He Wenqiang1,Qiao Nidan1,Ma Zengyi1,Ji Chenxing1,Shi Chengzhang1,Zhou Xiang1,Wang Yi2,Zeng Fangfang2,Zhang Li2,Gong Wei2,Cao Zhan3,Zhou Peng4,Melnikov Vladimir4,Ye Hongying2,Li Yiming2,Zhang Zhaoyun2,He Min2,Qin Huanlong3,Zhang Yichao15678ORCID

Affiliation:

1. Department of Neurosurgery, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

2. Department of Endocrinology and Metabolism, Huashan Hospital, Shanghai Medical College, Fudan University, Shanghai, China

3. Diagnostic and Treatment Center for Refractory Diseases of Abdomen Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai, China

4. Shanghai Medical College, Fudan University, Shanghai, China

5. National Center for Neurological Disorders, Shanghai, China

6. Shanghai Key Laboratory of Brain Function and Restoration and Neural Regeneration, Shanghai, China

7. Neurosurgical Institute of Fudan University, Fudan University, Shanghai, China

8. Shanghai Clinical Medical Center of Neurosurgery, Shanghai, China

Abstract

Dysbiosis of gut microbiota is associated not only with intestinal disorders but also with numerous extraintestinal diseases. Growth hormone-secreting pituitary adenoma (GHPA) is an insidious disease with persistent hypersecretion of GH and IGF-1, causing increased morbidity and mortality.

Funder

National Natural Science Foundation of China

Shanghai Hospital Development Center

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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