Circularization of rv0678 for Genotypic Bedaquiline Resistance Testing of Mycobacterium tuberculosis

Author:

Limberis Jason D.1ORCID,Nalyvayko Alina1,Ernst Joel D.1,Metcalfe John Z.2

Affiliation:

1. Division of Experimental Medicine, University of California, San Francisco, California, USA

2. Division of Pulmonary and Critical Care Medicine, Zuckerberg San Francisco General Hospital and Trauma Centre, University of California, San Francisco, California, USA

Abstract

Antimicrobial resistance is a global health threat, and drug resistant tuberculosis is a principal cause of antimicrobial resistance-related fatality. The long turnaround time and the need for high containment biological laboratories of phenotypic growth-based Mycobacterium tuberculosis drug susceptibility testing often commit patients to months of ineffective treatment, and there is a groundswell of effort in shifting from phenotypic to sequencing-based genotypic assays.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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