Association of Cervical Dysbacteriosis, HPV Oncogene Expression, and Cervical Lesion Progression-Reference-Cited by-同舟云学术

Association of Cervical Dysbacteriosis, HPV Oncogene Expression, and Cervical Lesion Progression

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Liu Hang¹^ORCID,Liang Hua²,Li Di¹,Wang Ming¹^ORCID,Li Yan¹

Affiliation:

1. Department of Clinical Laboratory, Renmin Hospital of Wuhan University, Wuhan, China

2. Department of Obstetrics and Gynecology, Renmin Hospital of Wuhan University, Wuhan, China

Abstract

The main findings of this study were that we clarified the associations of the different bacterial species with the expression of human papillomavirus (HPV) oncogenes at different stages of cervical cancer. Along with the severity of cervical lesions, the abundance of the genus and species of Lactobacillus obviously declined, while the aerobic and anaerobic bacteria, as well as the prevalence and expression of HPV E6/E7 oncogene, were increased dramatically.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00151-22

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