Cervical Squamous Intraepithelial Lesions Are Associated with Differences in the Vaginal Microbiota of Mexican Women-Reference-Cited by-同舟云学术

Cervical Squamous Intraepithelial Lesions Are Associated with Differences in the Vaginal Microbiota of Mexican Women

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Nieves-Ramírez M. E.¹²³⁴,Partida-Rodríguez O.¹²^ORCID,Moran P.²,Serrano-Vázquez A.²,Pérez-Juárez H.²,Pérez-Rodríguez M. E.³⁴,Arrieta M. C.⁵^ORCID,Ximénez-García C.²,Finlay B. B.¹⁶⁷^ORCID

Affiliation:

1. Michael Smith Laboratories, Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

2. Laboratorio de Inmunología, Unidad de Investigación de Medicina Experimental, Facultad de Medicina, Universidad Nacional Autónoma de México, Mexico City, Mexico

3. Department of Physiology and Pharmacology, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

4. Department of Pediatrics, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada

5. Laboratorio de Inmunología, UAEM Pediatría del Centro Médico Nacional SXXI, Instituto Mexicano del Seguro Social, Mexico City, Mexico

6. Department of Microbiology and Immunology, University of British Columbia, Vancouver, British Columbia, Canada

7. Department of Biochemistry and Molecular Biology, University of British Columbia, Vancouver, British Columbia, Canada

Abstract

Human papillomavirus (HPV) plays a critical role in cervical carcinogenesis but is not sufficient for cervical cancer development, indicating the involvement of other factors. The vaginal microbiota is an important factor in controlling infections caused by HPV, and, depending on its composition, it can modulate the microenvironment in vaginal mucosa against viral infections.

Funder

PAPIIT DGAPA UNAM

CONACYT MEXICO

Gouvernement du Canada | Canadian Institutes of Health Research

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00143-21

Reference61 articles.

1. From squamous intraepithelial lesions to cervical cancer: Circulating microRNAs as potential biomarkers in cervical carcinogenesis