A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model-Reference-Cited by-同舟云学术

A High Daptomycin Dose Is Associated with Better Bacterial Clearance in Infections Caused by Vancomycin-Resistant Enterococcus faecium Regardless of Daptomycin Minimum Inhibitory Concentration in a Rat Infective Endocarditis Model

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Wang Jann-Tay¹,Yang Chia-Jui²³,Yang Jia-Ling¹,Lin Shu-Wen⁴⁵⁶,Chuang Yu-Chung¹^ORCID,Sheng Wang-Huei¹,Chen Yee-Chun¹,Chang Shan-Chwen¹

Affiliation:

1. Department of Internal Medicine, National Taiwan University Hospital, Taipei, Taiwan

2. Department of Internal Medicine, Far Eastern Memorial Hospital, New Taipei City, Taiwan

3. School of Medicine, National Yang Ming Chiao Tung University, Taipei, Taiwan

4. School of Medicine, National Taiwan University, Taipei, Taiwan

5. Department of Pharmacy, National Taiwan University Cancer Center, Taipei, Taiwan

6. Graduate Institute of Clinical Pharmacy, National Taiwan University College of Medicine, Taipei, Taiwan

Abstract

Using a rat IE model with pharmacokinetic analysis, the treatment response of VREf IE was found to be daptomycin dose-dependent, presented as Cmax /MIC or as the 24 h area under the concentration-time curve (AUC 0–24 )/MIC. Daptomycin 90 mg/kg s.c. significantly reduced the bacterial load against DSE and DNSE.

Funder

Far Eastern Memorial Hospital

Ministry of Health and Welfare

Ministry of Science and Technology, Taiwan

National Taiwan University Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02551-22

Reference47 articles.