Metagenomic Shotgun Sequencing of Endocervical, Vaginal, and Rectal Samples among Fijian Women with and without Chlamydia trachomatis Reveals Disparate Microbial Populations and Function across Anatomic Sites: a Pilot Study

Author:

Bommana Sankhya1ORCID,Richards Gracie1,Kama Mike2,Kodimerla Reshma1,Jijakli Kenan3,Read Timothy D.3ORCID,Dean Deborah14567ORCID

Affiliation:

1. Department of Pediatrics, University of California San Francisco, Oakland, California, USA

2. Ministry of Health and Medical Services, Suva, Fiji

3. Department of Medicine, Emory University School of Medicine, Atlanta, Georgia, USA

4. Department of Medicine, University of California San Francisco, San Francisco, California, USA

5. Department of Bioengineering, Joint Graduate Program, University of California San Francisco and University of California Berkeley, San Francisco, California, USA

6. Bixby Center for Global Reproductive Health, University of California San Francisco, San Francisco, California, USA

7. Benioff Center for Microbiome Medicine, University of California San Francisco, San Francisco, California, USA

Abstract

Chlamydia trachomatis is the primary cause of bacterial sexually transmitted infections worldwide, with a disturbing increase in annual rates. While there is a plethora of data on healthy and pathogenic vaginal microbiomes—defining microbial profiles and associations with sexually transmitted infections (STIs)—far fewer studies have similarly examined the endocervix or rectum.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference89 articles.

1. WHO. 2018. Report on global sexually transmitted infection surveillance. World Health Organization, Geneva, Switzerland.

2. CDC. 2019. Sexually transmitted disease surveillance. Centers for Disease Control and Prevention, Atlanta, GA.

3. WHO Regional Office for the Western Pacific. 2012. WHO multi-country cooperation strategy for the Pacific 2013–2017. WHO Regional Office for the Western Pacific, Manila, Philippines.

4. Chlamydia in the Pacific Region, the Silent Epidemic

5. Prevalence of sexually transmitted diseases and human immunodeficiency virus among women attending prenatal services in Apia, Samoa

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