Mucin Protein of Aedes aegypti Interacts with Dengue Virus 2 and Influences Viral Infection

Author:

Yadav Karuna1,Rana Vipin Singh12,Anjali 1,Saurav Gunjan Kumar13,Rawat Nitish1,Kumar Ankit4,Sunil Sujatha4ORCID,Singh Om P.5,Rajagopal Raman1ORCID

Affiliation:

1. Gut Biology Laboratory, Department of Zoology, University of Delhi, New Delhi, India

2. Department of Veterinary Medicine, University of Maryland, College Park, Maryland, USA

3. Department of Zoology, Rajiv Gandhi University, Doimukh, Arunachal Pradesh, India

4. Vector Borne Disease Group, International Centre for Genetic Engineering and Biotechnology, New Delhi, India

5. National Institute of Malaria Research, New Delhi, India

Abstract

Identification of interacting protein partners of DENV in the insect vector Aedes aegypti is crucial for designing vector control-based strategies and for understanding the molecular mechanism DENV uses to modulate the host, gain entry, and survive successfully. Similar proteins can be used in generating transmission-blocking vaccines.

Funder

Council of Scientific and Industrial Research, India

DST | Science and Engineering Research Board

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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