A Structurally Characterized <i>Staphylococcus aureus</i> Evolutionary Escape Route from Treatment with the Antibiotic Linezolid-Reference-Cited by-同舟云学术

A Structurally Characterized Staphylococcus aureus Evolutionary Escape Route from Treatment with the Antibiotic Linezolid

Published:2022-08-31 Issue:4 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Perlaza-Jiménez Laura¹²,Tan Kher-Shing¹²,Piper Sarah J.³⁴,Johnson Rachel M.³⁴,Bamert Rebecca S.¹²,Stubenrauch Christopher J.¹²^ORCID,Wright Alexander⁵,Lupton David⁵,Lithgow Trevor¹²^ORCID,Belousoff Matthew J.²³⁴^ORCID

Affiliation:

1. Centre to Impact AMR, Monash University, Clayton, Victoria, Australia

2. Infection Program, Biomedicine Discovery Institute and Department of Microbiology, Monash University, Clayton, Victoria, Australia

3. Drug Development Biology, Monash Institute of Pharmaceutical Sciences, Parkville, Victoria, Australia

4. Centre for Cryo-electron Microscopy of Membrane Proteins, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, Victoria, Australia

5. School of Chemistry, Monash University, Clayton, Victoria, Australia

Abstract

Antibiotic resistance poses a critical problem to human health and decreases the utility of these lifesaving drugs. Of particular concern is the “superbug” methicillin-resistant Staphylococcus aureus (MRSA), for which treatment of infection requires the use of last-line antibiotics, including linezolid.

Funder

DOD | US Army | MEDCOM | Congressionally Directed Medical Research Programs

Department of Health | National Health and Medical Research Council

Department of Education and Training | Australian Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00583-22

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