Analysis of an IncR Plasmid Carrying bla NDM-1 Linked to an Azithromycin Resistance Region in Enterobacter hormaechei Involved in an Outbreak in Quebec

Author:

Doualla-Bell Florence1,Boyd David A.2,Savard Patrice34,Yousfi Khadidja13,Bernaquez Isabelle1,Wong Simon1,Usongo Valentine1,Mataseje Laura F.2,Mulvey Michael R.2,Bekal Sadjia13

Affiliation:

1. Laboratoire de santé publique du Québec, Institut national de santé publique du Québec, Sainte-Anne-de-Bellevue, Quebec, Canada

2. National Microbiology Laboratory, Public Health Agency of Canada, Winnipeg, Manitoba, Canada

3. Département de microbiologie, infectiologie et immunologie, Université de Montréal, Montréal, Quebec, Canada

4. Département clinique de médecine des laboratoires OPTILAB-CHUM and CRCHUM, Université de Montréal, Montréal, Quebec, Canada

Abstract

Analyzing the genetic environment of clinically relevant MDR genes can provide information on the way in which such genes are maintained and disseminated. Understanding this phenomenon is of interest for clinicians as it can also provide insight on where these genes might have been sourced, possibly supporting outbreak investigations.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference13 articles.

1. Critically important antimicrobials for human medicine World Health Organization. 2018. https://apps.who.int/iris/bitstream/handle/10665/312266/9789241515528-eng.pdf.

2. Global action plan on antimicrobial resistance World Health Organization. 2015. https://web.archive.org/web/20210225115924/http://www.who.int/antimicrobial-resistance/publications/global-action-plan/en/.

3. Doualla-Bell F Lefebvre B. 2020. Surveillance de laboratoire des souches d’entérobactéries résistantes aux carbapénèmes isolées au Québec en 2019. Institut national de santé publique du Québec. https://www.inspq.qc.ca/sites/default/files/publications/2723_surveillance_enterobacteires_resistantes_carbapenemes_2019.pdf.

4. Plasmids carrying antimicrobial resistance genes in Enterobacteriaceae

5. blaNDM-1 Carriage on IncR Plasmid in Enterobacteriaceae Strains

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