First Molecular Detection and Genetic Analysis of a Novel Porcine Circovirus (Porcine Circovirus 4) in Dogs in the World

Author:

Zhang Liu-Hui1,Wang Tong-Xuan1,Fu Peng-Fei2,Zhao You-Yi1,Li Hong-Xuan1,Wang Dong-Mei3,Ma Shi-Jie1,Chen Hong-Ying1ORCID,Zheng Lan-Lan1

Affiliation:

1. International Joint Research Center of National Animal Immunology, College of Veterinary Medicine, Henan Agricultural University, Zhengzhou, Henan Province, People’s Republic of China

2. College of Life Science and Engineering, Henan University of Urban Construction, Pingdingshan, Henan Province, People’s Republic of China

3. Lushan Dabei Agriculture and Animal Husbandry Food Co., Ltd., Lushan, Henan Province, People’s Republic of China

Abstract

This study is the first to report the presence of PCV4 in dogs worldwide, and the first complete genome sequence was obtained from a dog affected with diarrhea. Three genotypes of PCV4 strains (PCV4a, PCV4b, and PCV4c) were determined, as supported by specific amino acid markers (V239L for open reading frame 1 [ORF1] and N27S R28G and M212L for ORF2).

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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