Transposable Element Insertions into the Escherichia coli Polysialic Acid Gene Cluster Result in Resistance to the K1F Bacteriophage

Author:

Styles Kathryn M.1ORCID,Locke Rebecca K.2,Cowley Lauren A.2,Brown Aidan T.3,Sagona Antonia P.1ORCID

Affiliation:

1. School of Life Sciences, University of Warwick, Coventry, United Kingdom

2. Milner Centre for Evolution, Department of Biology & Biochemistry, University of Bath, Bath, United Kingdom

3. School of Physics and Astronomy, University of Edinburgh, Edinburgh, United Kingdom

Abstract

Bacteriophages have many potential uses in industry and the clinical environment as an antibacterial control measure. One of their uses, phage therapy, is an appealing alternative to antibiotics due to their high specificity.

Funder

UKRI | Engineering and Physical Sciences Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Reference42 articles.

1. Genetically modified bacteriophages

2. Jault P, Leclerc T, Resch G, Que Y-A, Pirnay J-P, Jennes S, Rousseau A-F. 2017. Evaluation of phage therapy for the treatment of Escherichia coli and Pseudomonas aeruginosa burn wound infections (Phase I-II clinical trial). Clamart, France.

3. Phage Therapy: What Have We Learned?

4. A Review of Using Mathematical Modeling to Improve Our Understanding of Bacteriophage, Bacteria, and Eukaryotic Interactions

5. The Antimicrobial Resistance Crisis: Causes, Consequences, and Management

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