Attenuation of Avian Flavivirus by Rewiring the Leucine and Serine Codons of Its E-NS1 Protein toward Stop Mutation To Redirect Virus Evolution-Reference-Cited by-同舟云学术

Attenuation of Avian Flavivirus by Rewiring the Leucine and Serine Codons of Its E-NS1 Protein toward Stop Mutation To Redirect Virus Evolution

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Guo Jiaqi¹,He Yu¹,Wang Xiaoli¹,Merits Andres²^ORCID,Wang Mingshu¹³⁴,Jia Renyong¹³⁴,Zhu Dekang³⁴^ORCID,Liu Mafeng¹³⁴^ORCID,Zhao Xinxin¹³⁴,Yang Qiao¹³⁴,Wu Ying¹³⁴,Zhang Shaqiu¹³⁴,Huang Juan¹³⁴,Mao Sai¹³⁴,Ou Xumin¹³⁴,Gao Qun¹³⁴,Sun Di¹³⁴,Tian Bin¹³⁴,Cheng Anchun¹³⁴^ORCID,Chen Shun¹³⁴^ORCID

Affiliation:

1. Institute of Preventive Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China

2. Institute of Technology, University of Tartu, Tartu, Estonia

3. Research Center of Avian Disease, College of Veterinary Medicine, Sichuan Agricultural University, Chengdu, Sichuan, China

4. Key Laboratory of Animal Disease and Human Health of Sichuan Province, Sichuan Agricultural University, Chengdu, Sichuan, China

Abstract

Flaviviruses are medically important arboviruses that threaten public health, but no approved treatments are currently available. Vaccines prevent flavivirus infection.

Funder

China Central and Eastern European Countries Joint Education Project

Sichuan Provincial Department of Science and Technology International Scientific and Technological Innovation Cooperation

Program Sichuan Veterinary Medicine and Drug Innovation Group of China Agricultural Research System

China Agricultural Research System

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02921-22

Reference35 articles.

1. THE USE OF YELLOW FEVER VIRUS MODIFIED BY IN VITRO CULTIVATION FOR HUMAN IMMUNIZATION

2. Intra-nasal infection of macaques with Yellow Fever (YF) vaccine strain 17D: a novel and economical approach for YF vaccination in man

3. Phenotypic and genotypic characteristics of Japanese encephalitis attenuated live vaccine virus SA14-14-2 and their stabilities

4. Study on the protective efficacy of SA14-14-2 attenuated Japanese encephalitis against different JE virus isolates circulating in China

5. Attenuation of RNA viruses by redirecting their evolution in sequence space