Cefotaxime Exposure Selects Mutations within the CA-Domain of <i>envZ</i> Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella-Reference-Cited by-同舟云学术

Cefotaxime Exposure Selects Mutations within the CA-Domain of envZ Which Promote Antibiotic Resistance but Repress Biofilm Formation in Salmonella

Published:2022-06-29 Issue:3 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Trampari Eleftheria¹,Zhang Chuanzhen¹²³,Gotts Kathryn¹,Savva George M.¹,Bavro Vassiliy N.⁴,Webber Mark¹⁵^ORCID

Affiliation:

1. Quadram Institute Bioscience, Norwich, United Kingdom

2. National Risk Assessment Laboratory for Antimicrobial Resistance of Animal Original Bacteria, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

3. Guangdong Key Laboratory for Veterinary Drug Development and Safety evaluation, College of Veterinary Medicine, South China Agricultural University, Guangzhou, China

4. School of Biological Sciences, University of Essex, Colchester, United Kingdom

5. Medical School, University of East Anglia, Norfolk, United Kingdom

Abstract

Understanding mechanisms of antibiotic resistance is crucial to guide how best to use antibiotics to minimize emergence of resistance. We used a laboratory evolution system to study how Salmonella responds to cefotaxime in both planktonic and biofilm conditions.

Funder

UKRI | Biotechnology and Biological Sciences Research Council

UKRI | Medical Research Council

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.02145-21

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