Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment-Reference-Cited by-同舟云学术

Genetic Adaptation and Acquisition of Macrolide Resistance in Haemophilus spp. during Persistent Respiratory Tract Colonization in Chronic Obstructive Pulmonary Disease (COPD) Patients Receiving Long-Term Azithromycin Treatment

Published:2023-02-14 Issue:1 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Carrera-Salinas Anna¹,González-Díaz Aida¹²,Ehrlich Rachel L.³,Berbel Dàmaris¹²,Tubau Fe¹²,Pomares Xavier⁴,Garmendia Junkal²⁵,Domínguez M. Ángeles¹⁶⁷,Ardanuy Carmen¹²⁷,Huertas Daniel⁸,Marín Alicia²⁹,Montón Conchita⁴,Mell Joshua Chang³,Santos Salud²¹⁰¹¹,Marti Sara¹²¹¹^ORCID

Affiliation:

1. Microbiology Department, Hospital Universitari de Bellvitge, IDIBELL-UB, Barcelona, Spain

2. Research Network for Respiratory Diseases (CIBERES), ISCIII, Madrid, Spain

3. Department of Microbiology and Immunology, Center for Genomic Sciences, Drexel University College of Medicine, Philadelphia, Pennsylvania, USA

4. Department of Respiratory Medicine, Hospital de Sabadell, Hospital Universitari Parc Taulí, Institut d’Investigació i Innovació Parc Taulí I3PT, Universitat Autònoma de Barcelona, Sabadell, Spain

5. Instituto de Agrobiotecnología, CSIC-Gobierno de Navarra, Mutilva, Spain

6. Research Network for Infectious Diseases (CIBERINFEC), ISCIII, Madrid, Spain

7. Department of Pathology and Experimental Therapeutics, School of Medicine, University of Barcelona, Barcelona, Spain

8. Department of Respiratory Medicine, Hospital Residència Sant Camil, Consorci Sanitari Alt Penedès-Garraf, Barcelona, Spain

9. Department of Respiratory Medicine, Hospital Universitari Germans Trias i Pujol, Barcelona, Spain

10. Department of Respiratory Medicine, Hospital Universitari de Bellvitge, IDIBELL-UB, Barcelona, Spain

11. Department of Medicine, School of Medicine, University of Barcelona, Barcelona, Spain

Abstract

The immunomodulatory properties of azithromycin reduce the frequency of exacerbations and improve the quality of life of COPD patients. However, long-term administration may alter the respiratory microbiota, such as Haemophilus influenzae , an opportunistic respiratory colonizing bacteria that play an important role in exacerbations.

Funder

MEC | Instituto de Salud Carlos III

Fundacio Catalana de Pneumologia FUCAP

Centro de Investigaciones Biomedicas en Red Enfermedades Respiratorias

Menarini

Amazon Web Services

Ministerio de Ciencia, Innovación y Universidades

Ministerio de Educación y Cultura

Sociedad Española de Neumología y Cirugía Torácica

Publisher

American Society for Microbiology

Subject