Sputum Microbiome and Chronic Obstructive Pulmonary Disease in a Rural Ugandan Cohort of Well-Controlled HIV Infection

Author:

Kayongo Alex12ORCID,Bartolomaeus Theda Ulrike Patricia3456,Birkner Till456,Markó Lajos3456,Löber Ulrike3456,Kigozi Edgar2,Atugonza Carolyne2,Munana Richard7,Mawanda Denis1,Sekibira Rogers1,Uwimaana Esther12,Alupo Patricia1,Kalyesubula Robert89,Knauf Felix7,Siddharthan Trishul10,Bagaya Bernard S.2,Kateete David P.2,Joloba Moses L.2,Sewankambo Nelson K.9,Jjingo Daudi1112,Kirenga Bruce19,Checkley William1314,Forslund Sofia K.345615ORCID

Affiliation:

1. Makerere University Lung Institute, Makerere University College of Health Sciences, Kampala, Uganda

2. Makerere University, College of Health Sciences, Department of Immunology and Molecular Biology, Kampala, Uganda

3. Charité-Universitätsmedizin Berlin, Corporate Member of Freie Universität Berlin, Humboldt-Universität zu Berlin, and Berlin Institute of Health, Berlin, Germany

4. Experimental and Clinical Research Center, A Cooperation of Charité - Universitätsmedizin Berlin and Max Delbrück Center for Molecular Medicine, Berlin, Germany

5. Max Delbrück Center for Molecular Medicine in the Helmholtz Association, Berlin, Germany

6. German Centre for Cardiovascular Research, Berlin, Germany

7. Department of Nephrology and Medical Intensive Care, Charité-Universitätsmedizin Berlin, Berlin, Germany

8. African Community Center for Social Sustainability (ACCESS), Department of Research, Nakaseke, Uganda

9. Makerere University, College of Health Sciences, Department of Medicine, Kampala, Uganda

10. University of Miami, School of Medicine, Division of pulmonary and critical care medicine, Miami, Florida, USA

11. Makerere University, College of Computing and Information Sciences, Department of Computer Science, Kampala, Uganda

12. African Center of Excellence in Bioinformatics and Data Science, Infectious Diseases Institute, Kampala, Uganda

13. Division of Pulmonary and Critical Care Medicine, Johns Hopkins University, Baltimore, Maryland, USA

14. Center for Global Non-Communicable Disease Research and Training, School of Medicine, Johns Hopkins University, Baltimore, Maryland, USA

15. Berlin Institute of Health (BIH), Berlin, Germany

Abstract

Even with ART available, HIV-infected individuals are at high risk of suffering comorbidities, as shown by the high prevalence of noninfectious lung diseases in the HIV population. Recent studies have suggested a role for the respiratory microbiota in driving chronic lung inflammation.

Funder

GlaxoSmithKline

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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