Rational Use of Microbiological Tests in the Diagnosis of Central Nervous System Infections Using Restrictive Criteria: a Retrospective Study

Author:

Ngo Nsoga M. T.12ORCID,Pérez-Rodriguez F. J.3ORCID,Mamin A.3,L’Huillier A. G.234ORCID,Cherkaoui A.25ORCID,Kaiser L.123,Schibler M.123

Affiliation:

1. Division of Infectious Diseases, Department of Medicine, Geneva University Hospitals, Geneva, Switzerland

2. Faculty of Medicine, University of Geneva, Geneva, Switzerland

3. Laboratory of Virology, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland

4. Pediatric Infectious Diseases Unit, Department of Women, Children and Adolescent Medicine, Geneva University Hospitals, Geneva, Switzerland

5. Laboratory of Bacteriology, Division of Laboratory Medicine, Department of Diagnostics, Geneva University Hospitals, Geneva, Switzerland

Abstract

Microbiological testing in general and in the setting of central nervous system (CNS) infection in particular are often excessive, leading to superfluous laboratory work and costs. In this regard, restrictive criteria, named Reller criteria, have been developed to reduce unnecessary CSF herpes simplex virus 1 (HSV-1) PCR testing when suspecting encephalitis.

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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