Neutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice-Reference-Cited by-同舟云学术

Neutrophil-Mediated Lung Injury Both via TLR2-Dependent Production of IL-1α and IL-12 p40, and TLR2-Independent CARDS Toxin after Mycoplasma pneumoniae Infection in Mice

Published:2021-12-22 Issue:3 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Tamiya Shigeyuki¹²,Yoshikawa Eisuke¹²,Ogura Monami¹²,Kuroda Etsushi³,Suzuki Koichiro⁴,Yoshioka Yasuo¹²⁴⁵⁶^ORCID

Affiliation:

1. Laboratory of Nano-Design for Innovative Drug Development, Graduate School of Pharmaceutical Sciences, Osaka University, Suita, Osaka, Japan

2. Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Research Institute for Microbial Diseases, Osaka University, Suita, Osaka, Japan

3. Department of Immunology and Medical Zoology, Hyogo College of Medicine, Nishinomiya, Hyogo, Japan

4. The Research Foundation for Microbial Diseases of Osaka University, Suita, Osaka, Japan

5. Vaccine Creation Group, BIKEN Innovative Vaccine Research Alliance Laboratories, Institute for Open and Transdisciplinary Research Initiatives, Osaka University, Suita, Osaka, Japan

6. Global Center for Medical Engineering and Informatics, Osaka University, Suita, Osaka, Japan

Abstract

Although Mp-induced pneumonia is usually a self-limiting disease, refractory life-threatening pneumonia is often induced. In addition, the development of alternative therapeutic strategies for Mp is expected because of the emergence of antibiotic-resistant Mp.

Funder

MEXT | Japan Society for the Promotion of Science

Nagai Memorial Research Scholarship from the Pharmaceutical Society of JAPAN

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01588-21

Reference49 articles.

1. Mycoplasma pneumoniaeand Its Role as a Human Pathogen

2. Mycoplasma pneumoniae from the Respiratory Tract and Beyond