Involvement of the Iron-Regulated Loci hts and fhuC in Biofilm Formation and Survival of Staphylococcus epidermidis within the Host

Author:

Oliveira Fernando123ORCID,Lima Tânia3,Correia Alexandra3,Silva Ana Margarida3,Soares Cristina4ORCID,Morais Simone4ORCID,Weißelberg Samira2,Vilanova Manuel356ORCID,Rohde Holger2ORCID,Cerca Nuno1ORCID

Affiliation:

1. Centre of Biological Engineering, LIBRO – Laboratory of Research in Biofilms Rosário Oliveira, University of Minho, Braga, Portugal

2. Institut für Medizinische Mikrobiologie, Virologie und Hygiene, Universitätsklinikum Hamburg-Eppendorf, Hamburg, Germany

3. i3S – Instituto de Investigação e Inovação em Saúde, Universidade do Porto, Porto, Portugal

4. REQUIMTE-LAQV, Instituto Superior de Engenharia do Porto, Instituto Politécnico do Porto, Porto, Portugal

5. IBMC, Instituto de Biologia Molecular e Celular, Universidade do Porto, Porto, Portugal

6. ICBAS-UP, Instituto de Ciências Biomédicas de Abel Salazar, Universidade do Porto, Porto, Portugal

Abstract

Staphylococcus epidermidis is one of the most important nosocomial pathogens and a major cause of central line-associated bloodstream infections. Once in the bloodstream, this bacterium must surpass severe iron restriction in order to survive and establish infection.

Funder

MEC | Fundação para a Ciência e a Tecnologia

Deutsche Forschungsgemeinschaft

Damp Stiftung

Joachim Herz Stiftung

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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