Unveiling a New Perspective on Distinguishing Omicron Breakthrough Cases and Postimmune COVID-19-Naive Individuals: Insights from Antibody Profiles-Reference-Cited by-同舟云学术

Unveiling a New Perspective on Distinguishing Omicron Breakthrough Cases and Postimmune COVID-19-Naive Individuals: Insights from Antibody Profiles

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Zhang Shihan¹²,Dong Chen³,Zhen Qian⁴,Shi Chao⁵,Tian Hua³,Li Chuchu³^ORCID,Kong Xiaoxiao³,Dai Qigang³,Huang Haodi³,Simayi Aidibai¹²,Zhu Fengcai³⁶⁷,Xu Yawen⁸,Hu Jianli³,Xu Ke³,Chen Liling⁹,Bao Changjun³¹⁰,Jin Hui¹²^ORCID,Zhu Liguo³⁶⁷¹¹

Affiliation:

1. Department of Epidemiology and Health Statistics, School of Public Health, Southeast University, Nanjing, China

2. Key Laboratory of Environmental Medicine Engineering, Ministry of Education, School of Public Health, Southeast University, Nanjing, China

3. Department of Acute Infectious Disease Control and Prevention, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China

4. Department of Acute Infectious Disease Control and Prevention, Changzhou Center for Disease Control and Prevention, Changzhou, China

5. Department of Acute Infectious Disease Control and Prevention, Wuxi Center for Disease Control and Prevention, Wuxi, China

6. National Health Commission (NHC) Key Laboratory of Enteric Pathogenic Microbiology, Jiangsu Provincial Center for Disease Control and Prevention, Nanjing, China

7. Key Laboratory of Infectious Diseases, School of Public Health, Nanjing Medical University, Nanjing, China

8. Yangzhou Center for Disease Control and Prevention, Yangzhou, China

9. Suzhou Center for Disease Control and Prevention, Suzhou, China

10. Jiangsu Province Engineering Research Center of Health Emergency, Nanjing, China

11. Jiangsu Key Lab of Cancer Biomarkers, Prevention and Treatment, Jiangsu Collaborative Innovation Center for Cancer Medicine, Nanjing Medical University, Nanjing, China

Abstract

This study fills a gap in the epidemiological evidence by investigating the value of serological indicators, particularly IgG and IgA levels, in the auxiliary diagnosis of COVID-19 infections when nucleic acid results are undetectable. The findings reveal that among Omicron breakthrough cases, both IgG and IgA antibody levels exhibit significant changes.

Funder

Social development foundation of Jiangsu Province

Postgraduate research and practice innovation program of Jiangsu Province

Nanjing Important Science & Technology Specific Projects

Top Talent Support Program for young and middle-aged people of Wuxi Health Committee

MOST | National Natural Science Foundation of China

Wuxi Science and Technology Association

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.01808-23

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