Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways-Reference-Cited by-同舟云学术

Beyond the Biosynthetic Gene Cluster Paradigm: Genome-Wide Coexpression Networks Connect Clustered and Unclustered Transcription Factors to Secondary Metabolic Pathways

Published:2021-10-31 Issue:2 Volume:9 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Kwon Min Jin¹^ORCID,Steiniger Charlotte¹^ORCID,Cairns Timothy C.¹^ORCID,Wisecaver Jennifer H.²³^ORCID,Lind Abigail L.⁴⁵^ORCID,Pohl Carsten¹^ORCID,Regner Carmen¹^ORCID,Rokas Antonis³⁵^ORCID,Meyer Vera¹^ORCID

Affiliation:

1. Chair of Applied and Molecular Microbiology, Institute of Biotechnology, Technische Universität Berlin, Berlin, Germany

2. Department of Biochemistry, Center for Plant Biology, Purdue University, West Lafayette, Indiana, USA

3. Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee, USA

4. Gladstone Institute for Data Science and Biotechnology, San Francisco, California, USA

5. Department of Biomedical Informatics, Vanderbilt University School of Medicine, Nashville, Tennessee, USA

Abstract

There is an urgent need for novel bioactive molecules in both agriculture and medicine. The genomes of fungi are thought to contain vast numbers of metabolic pathways involved in the biosynthesis of secondary metabolites with diverse bioactivities.

Funder

Marie Curie International Training Network QuantFung

National Science Foundation

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/Spectrum.00898-21

Reference77 articles.

1. Fungal secondary metabolism: regulation, function and drug discovery

2. Fungal secondary metabolism — from biochemistry to genomics