The Significance of Human Papillomavirus Receptors Related Genetic Variants in Cervical Cancer Screening

Author:

Xie Hongyu123,Wei Mingjing14,Yao Lifang45,Liu Yi46,Xie Xing14,Li Xiao1234ORCID

Affiliation:

1. Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Diseases, Women’s Hospital, School of Medicine Zhejiang University, Hangzhou, China

2. Clinical Research Center, Women’s Hospital, School of Medicine Zhejiang University, Hangzhou, China

3. Cancer Research Institute of Zhejiang University, Hangzhou, China

4. Department of Gynecologic Oncology, Women’s Hospital, School of Medicine Zhejiang University, Hangzhou, Zhejiang, China

5. Department of Obstetrics and Gynecology, Shaoxing Maternal and Child Health Hospital, Shaoxing, Zhejiang, China

6. Hangzhou Xixi Hospital, 2 Hengbu Street, Liuxia Town, Xihu District, Hangzhou City, Zhejiang Province, China

Abstract

Virus receptors are known to mediate virus attachment and further lead to virus infection of the host cells. In the current study, we investigated the relationship between single nucleotide polymorphisms (SNPs) in human papillomavirus (HPV) receptor associated genes and HPV susceptibility and clinical outcomes in Chinese women, and to explore the new triaging strategy for non-16/18 high-risk HPV infection.

Funder

MOST | National Key Research and Development Program of China

Key Research and Development Program of Zhejiang Province

MOST | National Natural Science Foundation of China

Open fund from Zhejiang Provincial Key Laboratory of Precision Diagnosis and Therapy for Major Gynecological Disease. Women’s Hospital Zhejiang University School of Medicine

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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