TWEAK-Fn14 Axis Induces Calcium-Associated Autophagy and Cell Death To Control Mycobacterial Survival in Macrophages

Author:

Chen Yi-Ming1234,Liu Po-Yu235,Tang Kuo-Tung4,Liu Hung-Jen2367ORCID,Liao Tsai-Ling123ORCID

Affiliation:

1. Department of Medical Research, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China

2. Rong Hsing Research Center for Translational Medicine, National Chung Hsing University, Taichung, Taiwan, Republic of China

3. Ph.D. Program in Translational Medicine, National Chung Hsing University, Taichung, Taiwan, Republic of China

4. Division of Allergy, Immunology and Rheumatology, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China

5. Division of Infection, Department of Internal Medicine, Taichung Veterans General Hospital, Taichung, Taiwan, Republic of China

6. Institute of Molecular Biology, National Chung Hsing University, Taichung, Taiwan, Republic of China

7. The iEGG and Animal Biotechnology Center, National Chung Hsing University, Taichung, Taiwan, Republic of China

Abstract

Tuberculosis remains a major cause of morbidity and mortality worldwide. We previously demonstrated a relationship between TWEAK and activation of the autophagic machinery, which promotes anti-mycobacterial immunity.

Funder

Ministry of Science and Technology, Taiwan

Taichung Veterans General Hospital

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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