Phenotypic Screens Identify Genetic Factors Associated with Gametocyte Development in the Human Malaria Parasite Plasmodium falciparum

Author:

Chawla Jyotsna12,Goldowitz Ilana3,Oberstaller Jenna2,Zhang Min2,Pires Camilla Valente2ORCID,Navarro Francesca4,Sollelis Lauriane56,Wang Chengqi C. Q.2,Seyfang Andreas12ORCID,Dvorin Jeffrey4ORCID,Otto Thomas D.5,Rayner Julian C.7,Marti Matthias356ORCID,Adams John H.12ORCID

Affiliation:

1. Department of Molecular Medicine, Morsani College of Medicine, University of South Florida, Tampa, Florida, USA

2. Center for Global Health and Infectious Diseases Research, College of Public Health, University of South Florida, Tampa, Florida, USA

3. Department of Immunology and Infectious Diseases, Harvard School of Public Health, Boston, Massachusetts, USA

4. Boston Children’s Hospital and Harvard Medical School, Harvard Medical School, Boston, Massachusetts, USA

5. Institute of Infection, Immunity, and Inflammation, College of Medical, Veterinary and Life Sciences, University of Glasgow, Glasgow, United Kingdom

6. Institute of Parasitology Zurich, VetSuisse Faculty, University of Zurich, Zurich, Switzerland

7. Cambridge Institute for Medical Research, University of Cambridge, Cambridge, United Kingdom

Abstract

Blocking human-to-vector transmission is an essential step toward malaria elimination. Gametocytes are solely responsible for achieving this transmission and represent an opportunity for therapeutic intervention.

Funder

HHS | NIH | NIAID | Division of Microbiology and Infectious Diseases, National Institute of Allergy and Infectious Diseases

Burroughs Wellcome Fund

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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