The Real-World Clinical Impact of Plasma mNGS Testing: an Observational Study-Reference-Cited by-同舟云学术

The Real-World Clinical Impact of Plasma mNGS Testing: an Observational Study

Published:2023-04-13 Issue:2 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Han Dongsheng¹²³,Yu Fei¹²³,Zhang Dan¹²³,Yang Qing¹,Xie Mengxiao¹,Yuan Lingjun¹,Zheng Jieyuan¹,Wang Jingchao¹,Zhou Jieting¹,Xiao Yanyan¹,Zheng Shufa¹²³,Chen Yu¹²³^ORCID

Affiliation:

1. Department of Laboratory Medicine, the First Affiliated Hospital, Zhejiang University school of Medicine, Hangzhou, Zhejiang, People's Republic of China

2. Key Laboratory of Clinical In Vitro Diagnostic Techniques of Zhejiang Province, Hangzhou, Zhejiang, People's Republic of China

3. Institute of Laboratory Medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China

Abstract

In this study, we show that although plasma mNGS testing significantly improved the detection rate of tested samples, nearly one in four (24.5%, 48/196) mNGS tests reported organisms were not clinically relevant, emphasizing the importance of cautious interpretation and infectious disease consultation. Moreover, based on clinical adjudication, plasma mNGS testing resulted in no or a negative impact in nearly half (43.5%, 64/147) of patients in the current study, indicating that how best to integrate this advanced method into current infectious disease diagnostic frameworks to maximize its clinical utility in real-world practice is an important question.

Funder

NSFC | NSFC-Zhejiang Joint Fund | 浙江省科学技术厅 | Natural Science Foundation of Zhejiang Province

National Natural Science Foundation of China

Zhejiang Provincial Natural Science Foundation for Distinguished Young Scholar

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.03983-22

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