Characterization of Immunological Responses to Borrelia Immunogenic Protein A (BipA), a Species-Specific Antigen for North American Tick-Borne Relapsing Fever

Author:

Curtis Michael W.1,Krishnavajhala Aparna1,Kneubehl Alexander R.2,Embers Monica E.3,Gettings Jenna R.4,Yabsley Michael J.45,Lopez Job E.12ORCID

Affiliation:

1. Department of Pediatrics, National School of Tropical Medicine, Baylor College of Medicine, Houston, Texas, USA

2. Department of Molecular Virology and Microbiology, Baylor College of Medicine, Houston, Texas, USA

3. Division of Immunology, Tulane National Primate Research Center, Tulane University Health Sciences, Covington, Louisiana, USA

4. Southeastern Cooperative Wildlife Disease Study, Department of Population Health, College of Veterinary Medicine, University of Georgia, Athens, Georgia, USA

5. Warnell School of Forestry and Natural Resources, University of Georgia, Athens, Georgia, USA

Abstract

Borrelia species transmitted by soft or hard ticks cause tick-borne relapsing fever (TBRF). This is a debilitating disease distributed worldwide but is likely underdiagnosed or misdiagnosed as Lyme disease due to poorly developed diagnostic tests. Borrelia turicatae , Borrelia parkeri , and Borrelia hermsii are three TBRF species previously implicated in human disease in North America.

Funder

HHS | NIH | National Institute of Allergy and Infectious Diseases

Texas Ecological Laboratories

NIH

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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