Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon-Reference-Cited by-同舟云学术

Identification of an Arylnaphthalene Lignan Derivative as an Inhibitor against Dengue Virus Serotypes 1 to 4 (DENV-1 to -4) Using a Newly Developed DENV-3 Infectious Clone and Replicon

Published:2023-08-17 Issue:4 Volume:11 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Hu Mingyue¹²³⁴,Li Wan-Fei⁵,Wu Tiantian¹²³⁶,Yang Yang¹²³,Chen Guoquan⁴,Chen Tongling¹²³,Liu Yongchen¹²³,Mei Yaqing¹²³,Wu De⁷,Wei Youchuan⁴,Luo Tingrong⁴,Zhang Hong-Jie⁵,Li Yi-Ping¹²³⁶^ORCID

Affiliation:

1. Institute of Human Virology, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

2. Department of Pathogen Biology and Biosecurity, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

3. Key Laboratory of Tropical Disease Control of Ministry of Education, Zhongshan School of Medicine, Sun Yat-sen University, Guangzhou, China

4. College of Animal Science and Veterinary Medicine, Guangxi University, Nanning, China

5. School of Chinese Medicine, Hong Kong Baptist University, Kowloon, Hong Kong, China

6. Department of Infectious Diseases, The Third Affiliated Hospital of Sun Yat-Sen University, Guangzhou, China

7. Institute of Pathogenic Microbiology, Center for Disease Control and Prevention of Guangdong, Guangzhou, China

Abstract

Dengue virus (DENV) is the most prevalent mosquito-transmitted virus, and there is no an anti-dengue drug. Reverse genetic systems representative of different serotype viruses are invaluable tools for the study of viral pathogenesis and antiviral drugs.

Funder

The Research Grant Council of the Hong Kong Special Administrative Region, China

Tha Innovation and Technology Commission of Hong Kong Special Administrative Region, China

MOST | National Key Research and Development Program of China

MOST | National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00423-23

Reference56 articles.

1. Molecular Insight into Dengue Virus Pathogenesis and Its Implications for Disease Control

2. The global distribution and burden of dengue

3. World Health Organization. 2019. WHO scales up response to worldwide surge in dengue. Released on 14 November 2019. https://www.who.int/news-room/feature-stories/detail/who-scales-up-response-to-worldwide-surge-in-dengue.

4. The continued threat of emerging flaviviruses

5. Global Evolutionary History and Dynamics of Dengue Viruses Inferred from Whole Genome Sequences