Inhibition of BET Family Proteins Suppresses African Swine Fever Virus Infection

Author:

Zhao Yaru1,Niu Qingli1ORCID,Yang Saixia1,Yang Jifei1,Zhang Zhonghui1,Geng Shuxian1,Fan Jie1,Liu Zhijie1,Guan Guiquan1,Liu Zhiqing2,Zhou Jia3,Hu Haitao4ORCID,Luo Jianxun1,Yin Hong15

Affiliation:

1. African Swine Fever Regional Laboratory, and State Key Laboratory of Veterinary Etiological Biology, Key Laboratory of Veterinary Parasitology of Gansu Province, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, Gansu, People’s Republic of China

2. Institute of Evolution and Marine Biodiversity, Ocean University of China, Qingdao, China

3. Chemical Biology Program, Department of Pharmacology and Toxicology, University of Texas Medical Branch, Galveston, Texas, USA

4. Department of Microbiology and Immunology, Institute for Human Infections and Immunity, University of Texas Medical Branch, Galveston, Texas, USA

5. Jiangsu Co-Innovation Center for the Prevention and Control of Important Animal Infectious Disease and Zoonosis, Yangzhou University, Yangzhou, People’s Republic of China

Abstract

Due to the continuing spread of the ASFV in the world and the lack of commercial vaccines, the development of improved control strategies, including antiviral drugs, is urgently needed. BRD4 is an important epigenetic factor and has been commonly used for drug development for tumor treatment.

Funder

National Natural Science Foundation of China

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

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