Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae from a Major Public Health Hospital in Singapore-Reference-Cited by-同舟云学术

Genomic Surveillance of Carbapenem-Resistant Klebsiella pneumoniae from a Major Public Health Hospital in Singapore

Published:2022-10-26 Issue:5 Volume:10 Page:
ISSN:2165-0497
Container-title:Microbiology Spectrum
language:en
Short-container-title:Microbiol Spectr

Author:

Teo Jocelyn Qi-Min¹²^ORCID,Tang Cheng Yee²,Tan Si Hui¹,Chang Hong Yi¹,Ong Sze Min³,Lee Shannon Jing-Yi¹,Koh Tse-Hsien⁴,Sim James Heng-Chiak⁴,Kwa Andrea Lay-Hoon¹⁵⁶^ORCID,Ong Rick Twee-Hee²^ORCID

Affiliation:

1. Department of Pharmacy, Singapore General Hospital, Singapore, Singapore

2. Saw Swee Hock School of Public Health, National University of Singapore and National University Health System, Singapore, Singapore

3. Department of Pharmacy, National University of Singapore, Singapore, Singapore

4. Department of Microbiology, Singapore General Hospital, Singapore, Singapore

5. Singhealth Duke-NUS Medicine Academic Clinical Programme, Singapore, Singapore

6. Emerging Infectious Diseases, Duke-National University of Singapore Medical School, Singapore, Singapore

Abstract

In this study, we characterized carbapenem-resistant Klebsiella pneumoniae clinical isolates collected over a 12-year period in the largest public acute-care hospital in Singapore using whole-genome sequencing. The results of this study demonstrate significant genomic diversity with the presence of well-known epidemic, multidrug-resistant clones amid a diverse pool of nonepidemic lineages.

Funder

MOH | National Medical Research Council

Saw Swee Hock School of Public Health Infectious Diseases Program

Publisher

American Society for Microbiology

Subject

Infectious Diseases,Cell Biology,Microbiology (medical),Genetics,General Immunology and Microbiology,Ecology,Physiology

Link

https://journals.asm.org/doi/pdf/10.1128/spectrum.00957-22

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